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Catheter-Based
Intramyocardial Injection of Autologous Skeletal Myoblasts
(Bioheart's MyoCell™) as a Primary Treatment of Ischemic
Heart Failure. Clinical Experience with Six-Month Follow-up. Pieter
C. Smits, M.D. Ph.D., Roberr-Jan M. Van Geuns, M.D., Ph.D.,
Don Poldermans, M.D., Ph.D., Manolis Bountioukos, M.D., Emile
E.M. Onderwater, Chi Hang Lee, M.D., Alex P.W.M. Maat, M.D.,
Patrick Serruys, M.D., Ph.D. Rotterdam, The Netherlands. Journal
of the American College of Cardiology, Vol. 42, No. 12, December
2003. View
this Article
MYOHEART
US Phase I Study - Interim Analysis - January 2007 Download
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Cellular
Therapy For Chronic Myocardial Disease: Nonsurgical Approaches.
Warren
Sherman
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Myocardial
Repair By Percutaneous Cell Transplantation Of Autologous
Skeletal Myoblasts As A Stand Alone Procedure In Post Myocardial
Infarction Chronic Heart Failure Patients.
Patrick
W. Serruys, MD, PhD on behalf of the BIOHEART European
005/006 and 008 study investigators. (3rd Annual Conference
on Cell Therapy for Cardiovascular Diseases, New York,
January, 2007)
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BIOHEART
MYOHEART DOSE ESCALATION U.S. CLINICAL STUDY INTERIM RESULTS
Intramyocardial
Myoblast Treatment for Ischemic Heart Failure: Results of
a Phase I Study.
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this Article
Cellular Cardiomyoplasty: Myocardial
Regeneration With Satellite Cell Implantation. Chiu RCJ,
Zibaitis A and RL Kao, Ann Thorac Surg 1995;60:12-8
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Clinical
Trials Offer Hope to Patients Willing to Take the Risks.
View
this Article Cellular
Cardiomyoplasty: Improvement of Left Ventricular Function Correlates
with the Release of Cardioactive Cytokines. Henning Ebelt,
Mirco Jungblut, Ying Zhang, Thomas Kubin, Sawa Kostin, Antje
Technau, Svetlana Oustanina, Sylvia Niebrügge, Jürgen
Lehmann, Karl Werdan and Thomas Braun .
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Skeletal
Myoblast for Cardiac Repair. A presentation from the Third
International Conference On Cell Therapy For Cardiovascular Disease
held in New York, 16th-19th January 2007.
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C2C12
Skeletal Muscle Cells Adopt Cardiac-Like Sodium Current Properties
in a Cardiac Cell Environment.
Intra-cardiac
transplantation of undifferentiated skeletal muscle cells (myoblasts)
has emerged as a promising therapy for myocardial infarct repair
and is already undergoing clinical trials.
View
this Article Electrophysiological
Consequence of Skeletal Myoblast Transplantation in Normal and
Infarcted Canine Myocardium. Kristen Fouts, BS, Brian Fernandes,
PhD, Niladri Mal, MD, Jinqiu Liu, MD, Kenneth R. Laurita, PhD.
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Editorial
Commentary on this Article: Infarction size is a far
greater contributor to arrhythmia risk than any other factor.
Myoblast injections have been shown to reduce scar size by
up to 70%. The very slight increase of arrhythmia risk of utilizing
myoblasts in healthy tissue is more than totally off set by
their ability to reduce scar size, by a long margin. Pluripotent
stem cells are slightly less pro-arrhythomogenic when injected
in healthy tissue but are far less likely to reduce infarction
scar size. The best study with pluripotent stem cells only
showed a 30% reduction, mostly due to recovery of hibernating
tissue not actual scar tissue reduction. Pluripotent stem cells
injected into scar tissue primarily become fibroblasts which
does not serve to reduce infarction size. Conclusion: Myoblasts
when able to form new contractile muscle in scar tissue and
thus reduce MI scar size serve to greatly REDUCE the
risk of arrhythmia's. MI size reduction provided by myoblast
injections has far greater impact on reducing arrhythmia risk
than does slight increased risk caused by injecting myoblasts
into healthy tissue.
Note -
Paper fails to address in short time period myoblasts injected
into healthy tissue migrate to scar tissue or disappear from
healthy tissue due to venous vacuum loss.
Repeated
Implantation is a More Effective Cell Delivery Method in Skeletal
Myoblast Transplantation for Rat Myocardial Infarction. Several
clinical trials are underway to determine whether autologous
skeletal myoblast transplantation is an effective and safe therapeutic
strategy for severe heart failure due to myocardial infarction
(MI). It remains unclear whether repeated skeletal myoblast implantation
is a feasible and effective cell delivery method for the infarcted
myocardium.
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Autologous
Stem Cells and Transmyocardial Laser Revascularization for Ischemic
Heart
Esha Ibrahim, Quan Zhu, D. Glenn Pennington, Charles E. Ganote and Race L.
Kao
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Intramyocardial
Injection Of Skeletal Myoblasts: Long-Term Follow-up with Pressure-Volume
Loops. Steendijk P, Smits PC, Valgimigli M, van der Giessen
WJ, Onderwater EE, Serruys PW. View
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the Full Article
From
Cardiac Repair To Cardiac Regeneration--Ready To Translate? HC
Ott and DA Taylor.
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an Abstract of this Article
Myoblast
Transplantation for Heart Repair – A Review of the State
of the Field.
Howard J. Leonhardt, Chairman & CEO Bioheart, Inc.
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an Abstract of this Article | Supportive Media: Davos
Cell Therapy Meeting Program
Electrophysiological
Consequence Of Skeletal Myoblast Transplantation In Normal And
Infarcted Canine Myocardium. The purpose of this study is
to test a hypothesis that injection of skeletal myoblasts (SkMbs)
into viable tissue may alter impulse conduction but that injections
into nonviable tissue (scar) will have negligible impact.
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Autologous
Skeletal Myoblast Transplantation Improved Hemodynamics and Left
Ventricular Function in Chronic Heart Failure Dogs. Kun-Lun
He MD, PhDa, Geng-Hua Yi PhDb, Warren Sherman MDc, Hua Zhou PhDa,
Ge-Ping Zhang MDb, Anguo Gu MDb, Race Kao PhDd, Howard B. Haimes
PhDe, John Harvey PhDe, Eric Roos PhDe, Desmond White PhDe, Doris
A. Taylor MD, PhDf, Jie Wang MD, PhDb and Daniel Burkhoff MD,
PhDb. View
this Article
Ventricular
Arrhythmia After Autologous Skeletal Myoblast Transplantation
In Patients With Postinfarction Heart Failure Could Be Controlled
By Amiodarone; Observations From Two Clinical Trials. Siminiak
T., Kalawski R., Jerzykowska O.Fiszer D., Ka³mucki P., Rozwadowska
N., Kurpisz M. View
this Article
Autologous
Intramyocardial Injection of Cultured Skeletal Muscle-Derived
Stem Cells in Patients with Non-Acute Myocardial Infarction. Jesús
Herrerosa, Felipe Prósper, , b, Ana Perezb, Juan J. Gaviraa,
María José, Garcia-Vellosoc, Joaquín Barbaa,
Pedro L. Sáncheze, Consuelo Cañizod, Gregorio,
Rábagoa, Josep M. Martí-Climentc, Milagros Hernándezb,
Natalia López-Holgadod, José María González-Santose,
Cándido Martín-Luengoe and Eduardo Alegriaa.
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Bioheart
Presentation: Myoblast versus Stem Cell - Transplantation for
Myocardial Repair
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Cellular
Therapy with AutologousSkeletal Myoblasts for IschemicHeart Disease
and Heart Failure.
View
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Safety
and Feasibility of Percutaneous Autologous Skeletal Myoblast
Transplantation for Ischemic Cardiomyopathy: Interim Analysis.
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Transplanted
Skeletal Myoblasts Can Fully Replace the Infarcted Myocardium
When They Survive in the Host in Large Numbers.
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Potential
of Skeletal Myoblast Transplantation for Ischemic Heart Disease.
Safety
and feasibility of autologous myoblast transplantation in
patients with ischemic cardiomyopathy: four-year follow-up.
View
this Article
History
of Cell Transplantation for Myocardial Regeneration: A First
in Cell Transplantation: Researchers Organize, Meet
Science; Jun 12, 1992; 256, 5063; Research Library Core, pg. 1522.
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Cellular
Cardiomyoplasty: Improvement Of Left Ventricular Function Correlates
With The Release Of Cardioactive Cytokine.
View
this Abstract
Myoblasts
Proliferate in Scar Tissue.
A
pilot study conducted on the use of stem cells to repair
the damaged heart muscle of four male patients with end-stage
heart failure is proving successful.
View
this Article
Safety
And Feasibility Of Percutaneous Autologous Skeletal Myoblast
Transplantation In The Coil-Infarcted Swine Myocardiumn.
Myoblast transplantation
is a promising new treatment for patients with congestive heart failure
and/or MI. Successful autologous skeletal myoblast transplantation
(ASMT) to the myocardium has been demonstrated in a variety of animal
models.
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UNIVERSITY
OF FLORIDA - Non-invasive Analysis Of Myoblast Transplants In
Rodent Cardiac Muscle.
KS
Cahill, S Germain, BJ Byrne, and GA Walter; Int J Cardiovasc
Imaging, December 1, 2004; 20(6): 593-8. Powell Gene Therapy
Center, University of Florida, Gainesville 32610, USA
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this Article
Myoblast
Transplantation for MI and CHF Treatment - Cell and Gene-Based
Therapies Show Promise in Treating Cardiovascular Disease.
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Multiple-Dose
Implantation is a Better Cell Delivery Method than Single-bolus
Implantation in Skeletal Myoblast Transplantation to Infarcted
Hearts. Goditha U Premaratne, Keiichi Tambara, Xue Lin, Naoki
Kaneemitsu, Hiroyuki Nakajima, Yan Teishi, Tadashi Ikeda, Masatoshi
Fujita, Masashi Komeda; Cardiovascular Surgery, Kyoto, Japan
View
this Article
Successful
Myoblast Transplantation In Fibrotic Muscles: No Increased Impairment
By The Connective Tissue1.
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Functional
Assessment Of Myoblast Transplantation For Cardiac Repair With
Magnetic Resonance Imaging.
van
den Bos EJ, Thompson RB, Wagner A, Mahrholdt H, Morimoto Y, Thomson
LE, Wang LH, Duncker DJ, Judd RM, Taylor DA. Departments of Cardiology,
Duke University Medical Center, Durham, NC 27710, USA
View
this Article
Factors
Related to the Efficacy of Skeletal Muscle Cell Transplantation
and Future Approaches with Control-Released Cell Growth Factors
and Minimally Invasive Surgery. View
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Direct Isolation
of Satellite Cells for Skeletal Muscle Regeneration.
Didier Montarras, Jennifer Morgan, Charlotte Collins, Fre´de´ric
Relaix, Ste´phane Zaffran, Ana Cumano Terence Partridge, Margaret Buckingham. View
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Cell
Transplantation for the Treatment of Acute Myocardial Infarction:
The Unique Capacity for Repair by Skeletal Muscle Satellite
Cells. Horackova M, Arora
R, Chen R, Armour JA, Cattini PA, Livingston R, Byczko Z. Department
of Physiology and Biophysics, Dalhousie University, Halifax,
Nova Scotia, Canada.
View
this Article
Effectiveness
of Transient Immunosuppression Using Cyclosporine for Xenomyoblast
Transplantation for Cardiac Repair. H.Kh.
Haider, S.J. Jiang, L. Ye, S. Aziz, P.K. Law, and E.K.W. Sim.
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POZNAN:
Percutaneous Myoblast Transplants Tested in Phase I Trial. Procedure
extracts leg muscle cells to grow patches that are grafted onto
scarred myocardium. View
this Article
Video-Assisted
Thoracoscopic Transplantation of Myoblasts Into the Heart. Thompson
RB, Parsa CJ, Van Den Bos EJ, Davis BH, Toloza EM, Klem I, Glower
DD, Taylor DA. View
this Article
Encouraging
Signs Follow Muscle Cell Transplantation Into Damaged Hearts
Pilot study paves way for larger trials of treatment to repair
scarring after heart attacks. View
this Report
Improved
Regional Left Ventricular Function After Successful Satellite
Cell Grafting In Rabbits with Myocardial Infarction. Blatt
A, Robinson D, Cotter G, Efrati S, Simantov Y, Bar I, Kaluski
E, Krakover R, Sidenko S, Evron Z, Lipa L, Posternak N, Nevo
Z, Vered Z., Cardiology Department, Assaf Harofeh Medical Center,
70300, Zerifin, Israel. View
this Article
Myoblasts
Survive 16 Weeks After Intracardiac Transfer and Start Differentiation. Gulbins
H, Pritisanac A, Anderson I, Uhlig A, Goldemund A, Daebritz S,
Meiser B, Reichart B., View
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BAM
articles on Cellular Cardiomyoplasty [Links
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browser window]
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Skeletal
Muscle Cell Grafts Fix Heart Damage - Transplants Aid In Full
Recovery After Heart Attack.
By Donalee Moulton, The Medical Post, April 13, 2004 Volume 40 Issue 15
View
this Article
Seeding
a Heart with Healing Cells - Doctors Hope Therapy Grows Muscle
in Place of Dead Tissue
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Information
Myocardial
Replacement Therapy
Tomasz Siminiak, MD, PhD, FESC; Maciej Kurpisz, MD, PhD.
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Cellular
Cardiomyoplasty: Clinical Application
Juan C. Chachques, MD, PhD, Christophe Acar, MD, Jesus Herreros, MD, Jorge
C. Trainini, MD, Felipe Prosper, MD, Nicola D’Attellis, MD, Jean-Noel
Fabiani, MD, and Alain F. Carpentier, MD, PhD
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Myoblast
Transplantation for Cardiac Repair: A Clinical Perspective
Husnain Kh. Haider, Alvin C.K. Tan, Salim Aziz, Juan C. Chachques, and Eugene
K.W. Sim
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Percutaneous
Autologous Myoblast Transplantation in the Treatment of Post-infarction
Myocardial Contractility Impairment - Report On Two Cases. Siminiak
T, Fiszer D, Jerzykowska O, Grygielska B, Kalmucki P, Kurpisz
M., University School of Medical Sciences, Department of Cardiology,
District Hospital, Poznan, Poland.
View
this Article
UF
To Research Stem Cell Treatments For Heart Disease.
University
of Florida researchers will play a key role in a new national network
designed to study stem cell treatments in patients with cardiovascular
disease.
View
this Article
Skeletal
Muscle Satellite Cells
Reproductive Biology and Endocrinology 2003; 1:101
Jennifer CJ Chen, David J. Goldhammer.
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Percutaneous
Transvenous Transplantation Of Autologous Myoblasts In The Treatment
Of Postinfarction Myocardial Contractility Impairment - Procedural
Feasibility And Safety. Tomasz Siminiak, Dorota Fiszer, Olga
Jerzykowska, Beata Grygielska, Piotr Kalmucki, Maciej Kurpisz.
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Cellular
cardiomyoplasty - A preliminary Clinical Report. Fumin Zhanga,
Xiang Gaob, Zhi-Jian Yianga, Wenzhu Maa, Chuanfu Lic and Race
L. Kaoc.
View
this Article
Cardiac
Transplantation of Skeletal Myoblasts for Heart Failure. Van
Den Bos EJ, Taylor DA, Department of Medicine, Division of Cardiology,
Duke University Medical Center, Durham, NC, USA.
View
this Article
Skeletal
Myoblast Transplantation During Bypass Grafting In The Treatment
Of Heart Failure-Phase I Clinical Trial Feasibility Study And
Early Results. Siminiak T, Kalawski R, Fiszer D, Jerzykowska
O, Rzezniczak J, Kurpisz M. University School of Medical Sciences,
J. Strus Hospital and Institute of Human Genetics, Polish Academy
of Sciences, Poznan, Poland.
View
this Article
Novel
Treatment For Heart Failure Being Tested. Nancy McVicar -
South Florida Sun-Sentinel.
View
this Article
Cellular
Cardiomyoplasty With Autologous Skeletal Myoblasts For Ischemic
Heart Disease And Heart Failure. Doris A. Taylor.
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Skeletal
Myoblasts Divide Further And Start Differentiation After Transplantation
Into Rat Myocardium. Gulbins H, Pritisanac A, Uhlig
A, Goldemund A, Haas U, Meiser B, Reichart B.
View
this Abstract
Endoventricular
Porcine Autologous Myoblast Transplantation Can Be Successfully
Achieved With Minor Mechanical Cell Damage. Bénédicte
Chazaud, Luc Hittinger, Corinne Sonnet, Stéphane Champagne,
Philippe Le Corvoisierc, Nicole Benhaiem-Sigauxe, Thierry Unterseeh,
Jinbo Su, Pascal Merlet, Alain Rahmouni, Jérôme
Garot, Romain Gherardi, and Emmanuel Teiger.
View
this Abstract
Cellular
Therapy Reverses Myocardial Dysfunction. Rajnoch C, Chachques
JC, Berrebi A, Bruneval P, Benoit MO,
Carpentier A.
View
this Abstract
Treatment
Of Heart Failure With Autologous Skeletal Myoblasts. Chachques
JC, Cattadori B, Herreros, J, Prosper F, Trainini JC, Blanchard
D, Fabiani JN, Carpentier A.
View
this Abstract
Incorporation
And Integration Of Implanted Myogenic And Stem Cells Into Native
Myocardial Fibers: Anatomic Basis For Functional Improvements. Edgar
G. Chedrawy, Jih-Shiuan Wang, Dao M. Nguyen, Dominique Shum-Tim,
Ray C. J. Chiu.
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Impact
of Autologous Skeletal Myoblast Transplantation on Hemodynamics
and Left Ventricular Function in Repeated Coronary Microembolization-Induced
Heart Failure in Awake Dogs. Kun-Lun He, Hwa Zhou, Geng-Hua
Yi, Eva Maria Becker, Race Kao, Jack Harvey, Anguo Gu, Ge-Ping
Zhang, Satoshi Mohri, Jie Wang, Daniel Burkhoff. Division of
Circulatory Physiology, Department of Medicine, College of Physicians
and Surgeons of Columbia University, New York City, N.Y., USA
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In Vitro Culture Of Muscle Derived
Stem Cells For Application In Human Cardiac Regenerative Therapy
By Means Of Cellular Cardiomyoplasty. Pérez A, Perez-Calvo
J, Herreros J, Barba J, Rábago G, Inogés S, Ariz G, Cosín J,
Gavira JJ, Rifón J, Hernández M, Rodríguez Calvillo M, Martin-Algarra,
Prósper F.
View
this Abstract
Satellite
Cells for Myocardial Regeneration. Race
L. Kao, Ph.D., Charlene Rizzo, Ph.D., George J. Magovern, M.D.
Allegheny-Singer Research Institute, Pittsbugh, PA 15212. THE
PHYSIOLOGISTAugust 1989; 32(4):220.
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Comparison of Benefits on Myocardial Performance
of Cellular Cardiomyoplasty with Skeletal Myoblasts and Fibroblasts. Taylor,
Doris A.; Atkins, B. Zane; Glower, Donald D.; Hopkins, M. Benjamin;
Hueman, Matthew T.; Hutcheson, Kelley A,
Cell Transplantation VOL. 9 NO. 3 May-June, 2000 PP. 359-368.
View
this Abstract
Regenerating Functional Myocardium: Improved Performance
After Skeletal Myoblast Transplantation. Taylor DA, Atkins
B, Hungspreugs P, Jones TR, Reedy MC, Hutcheson KA, Glower DD
and WE Kraus.
Nature Med. 1998. 4(8):929-933.
View
this Abstract
Cellular Cardiomyoplasty Improves Diastolic Properties
of Injured Heart. Atkins BZ, Hueman MT, Meuchel J, Hutcheson
KA, Glower DD and DA Taylor. J Surgical Res. 1999. 85,234-242.
View
this Abstract
Myoblast Cell Grafting into Heart Muscle: Cellular Biology
and Potential Applications. Kessler PD and BJ Byrne. Annu
Rev Physiol. 1999. Vol 61: 219-42.
South Floridian
Could Be First American To Test Revolutionary Heart Treatment. McVICAR, Nancy. Sun-Sentinel
Web-posted: 11:34 p.m. Feb. 18, 2001
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Mild-Mannered
Bioheart Founder Aims to Make Difference. BIOTECH,
January 10, 2000, page 7G
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Commentary:
Cellular Cardiomyoplasty With Autologous Skeletal Myoblasts
For Ischemic Heart Disease And Heart Failure. Doris
A Taylor, 10 September
2001 Curr Control Trials Cardiovasc Med 2001, 2:in press.
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Enhances
Ischemic Vasculogenesis and Angiogenesis via Vascular Endothelial
Growth Factor/Endothelial Nitric Oxide Synthase-Related Pathway. Ken-ichi
Hiasa, MD; Minako Ishibashi, MD; Kisho Ohtani, MD; Shujiro
Inoue, MD; Qingwei Zhao, MD; Shiro Kitamoto, MD; Masataka
Sata, MD; Toshihiro Ichiki, MD; Akira Takeshita, MD; Kensuke
Egashira, MD.