Weston, Florida

"Assisting Physicians to Develop Customized Care Plans to Prevent Heart Attacks and Cardiovascular Disease Based on Genotyping"

THE ODDS RATIO FOR CORONARY HEART DISEASE ASSOCIATED WITH THE PRIMARY RISK FACTORS
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Test Descriptions

PL^A2 Test", is a genetic test able to identify presence of the PL^A2 polymorphism (a point mutation) of DNA. Studies at Johns Hopkins and Ohio State University have linked the presence of this polymorphism with the effectiveness of aspirin in preventing myocardial infarction. Approximately 20-50% of the population in North America has the PL^A2 polymorphism and can effectively reduce their risk of myocardial infarction with aspirin therapy. (Related Information) The other 50-80% of people should consider another anti-platelet therapy such a Plavix" Clopidigrel or ticlopidine. The company believes all people at risk of a heart attack or stroke should have this test, including all patients undergoing bypass surgery, angioplasty or coronary stenting. BACK | BIOHEART CLINICAL PAPER SUMMARIES... | PL^A2 SLIDESHOW

Iron Sensitivity Test" is a genetic test able to identify presence of the hemachromatosis gene. This gene has been linked through studies to iron intake and heart disease. Hemachromatosis is a disease which allows too much iron to be absorbed from food. Utrecht University published a study of 12,239 women. Those who had just one copy of the hemochromatosis gene had double the risk of dying from heart disease or stroke, this data was confirmed by a similar study at the University of Kuopio in Finland. One in ten Americans have at least one copy of this gene. BACK

Salt Sensitivity Test", is a genetic test able to identify presence of variants of the HSD 11B2 gene (Allele A7/A7) which contribute to enhanced blood pressure response to salt. The prevalence of salt sensitivity was 35% in subjects with the allele A7/A7. Elevated blood pressure is a leading underlying cause of many forms of cardiovascular and heart disease. BACK

HDL Cholesterol Gene Test", is a genetic test under development designed to identify presence of the ATP- binding cassette transporter gene (ABC1). This gene regulates a protein that is crucial for intracellular cholesterol transport. HDL helps rid the body of artery clogging cholesterol. About half of heart disease patients have low HDL levels. BACK

Apolipoprotein E Test", is a genetic test under development designed to identify presence of the apoE polymorphism and the apoE e4/3 allele. Apolipoprotein E (apoE) is one of the genetic determinants of serum cholesterol values. The apoE e4 allele has been associated with advanced coronary heart disease and atherosclerosis of the aorta.

In men who are early middle age (<53 years) the apoE e4 allele is a significant genetic risk factor for coronary atherosclerosis. In older age other known risk factors of coronary heart disease play a more important role than the apoE polymorphisms. Men <53 years old with the apoE e4/3 genotype showed 61% larger total antherosclerotic lesion area in their right coronary artery and 26% larger area in left anterior descending artery than did men with the e3/3. BACK