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Doris Taylor, Ph.D. – Duke University
Work began: 1991
Type of Work: Autologous Myoblast Cell Therapy (regenerative satellite cells)
Additional Additives Being Studied: F.G.F., V.E.G.F, N.O.S.
Basic Procedure: Harvest skeletal muscle from thigh, separate immature myoblasts, culture to 10 billion cells, reinject into myocardium with needle catheter
No. of Animals Completed: Approximately 400
Type of Animals: Rabbits and Pigs
Injury Model: Cryoinfarction and Ligation Infarctions
Current Results: 50-70% improvement of cardiac performance
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Ray Chiu, M.D. – McGill University
Work Began: 1990
Type of Work: Autologous Bone Marrow Stromal Cell Derived Residual Cycling Stem Cells
Additional Additives Being Studied: V.E.G.F., N.O.S.
Basic Procedure: Harvest bone marrow biopsy, separate out residual cycling stem cells, culture, reinject into myocardium
No. of Animals Completed: Approximately 40
Type of Animals: Pigs, Dogs, Rabbits
Injury Model: Ligation Infarction, Balloon Infarction
Current Results: 50% improvement of cardiac performance
Latest Work: Transvecting Myoblasts with Growth Factors and Nitric Oxide Synthase
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Peter Law, Ph.D., M.D. – Cell Therapy Foundation, Memphis
Work Began: 1975
Type of Work: Allogenic Myoblast Cell Therapy
Additional Additives Being Studied: N.O.S., Electrical/Vibrational Stimulation
Basic Procedure: Harvest myoblasts from genotyped foreign donor, separate out immature myoblasts, culture to 50 billion cells, place in special serum free media, put on shelf, reinject immediately after infarction
No. of Animals Completed (OUTSIDE OF HEART): 600
No. of Human Cases for Repair of Muscle (OUTSIDE OF HEART): 200 Under Phase II I.N.D. moving to Phase III
Types of Animals: Rabbits and Pigs
Injury Model: None in most animals, Recently Ligation Infarction
Current Results: Muscle Function Substantially Improved, No Safety Problems
Latest Work: Using Cell Fusion Properties of Myoblasts in Culture with Cardiomyocytes Harvested From Patient
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Dan Burkhoff, Ph.D., M.D. – Columbia University New York
Work Began: 199?
Type of Work: Heart Failure Animal Model
Additional Additives Being Studied: Left Ventricular Assist Device
Basic Procedure: Use glass microsphere injections of many weeks to create simulation of heart failure in dog
No. of Animals Completed: ? NEW working with Bioheart.
Type of Animals: Dogs
Type of Injury: Glass microspheres slowly create ischemia over weeks - patchy
Current Results: Best Animal Model Simulation of Heart Failure Available
Latest Work: Using mixture of myoblasts, mesenchymal stem cells, growth factors and N.O.S. with L.V.A.D. to effect improvement of cardiac function – also basic study of safety of autologous myoblast cell therapy
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Syde Taheri, M.D. – University of Buffalo – Millard Fillmore Hospital
Work Began: 1975
Type of Work: Use of Omentum as Blood Supply to Infarcted Heart
Additional Additives Being Studied: Skeletal Muscle Myoblasts
Basic Procedure: With surgical or laproscopic means moving omentum and reattach to infarcted area of heart to improve blood supply and stitch in place patch of skeletal muscle myoblasts
No. of Animals: 22
Type of Animals: Dogs, Rabbits
Type of Injury: Ligation infarction of L.A.D.
Current Results: Substantial improvement of cardiac function
Latest Work: Laproscopic means of moving omentum to infarction
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Stu Williams, Ph.D. – University of Arizona Health Sciences
Work Began: 1980
Type of Work: Endothelial cell sodding, tissue engineering, delivery stystem testing, angiogenesis
Additional Additives Being Studied: Microvascular Fat
Basic Procedure: Harvest autologous endothelial cells – reinject into damaged organ. Also feasibility test comparison of various delivery systems.
No. of Animals: 30+, 2 for delivery systems
Type of Animals: Pigs
Type of Injury: Ligation infarction
Current Results: Improved Angiogenesis compared to needle mechanical irritation alone, delivery systems – endovascular, surgical and laproscopic proven feasibility.
Latest Work: Laproscopic means of injecting into myocardium
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Stephen Ellis, M.D. – Cleveland Clinic (agreement tentative still being finalized)
Work Began: New
Type of Work: Testing of additives to mix with immature myoblasts or stem cells to improve angiogenesis and myogenesis ie; NOS, Angiopoiten 1, SERCA 2, FGF, VEGF. Also work related to maximizing immortalized or hibernating cells for improvement of heart function.
Basic Procedure: Controlled ligation infarction, injection of cells directly into
myocardium.
Type of Animals: Dogs and Pigs
No. of Animals: New
Type of Injury: Controlled ligation infarction
Current Results: New
Latest Work: Determining 12 candidates additives for testing to improve angiogenesis and myogenesis
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Sam Ahn, M.D. – U.C.L.A.
Work Began: March 2000
Type of Work: Development of Laproscopic System for injecting cells into myocardium, moving omentum blood supply and transplanting viable cardiac myocytes into lesion.
Basic Procedure: 4 5mm holes in chest and abdomen provide laproscopic access to heart. One lung is partially collapsed. System is used to inject cells, move omentum blood cell and transplant cardiomyocytes.
Type of Animals: Pigs
No. of Animals: 2
Type of Injury: Controlled ligation infarction
Current Results: Feasibility proven
Latest Work: Biopsy and injection method improvement for transplantation of cardiomyocytes from viable heart to infracted lesion.